Federica Sotgia Selected Research

Ketones

9/2013	Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery.
5/2013	Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.
1/2013	Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer prevention.
1/2013	Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.
11/2012	Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.
11/2012	Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
11/2012	Ketone body utilization drives tumor growth and metastasis.
7/2012	Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells.
6/2012	Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.
1/2012	Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism.

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Federica Sotgia Research Topics

Disease

129	Neoplasms (Cancer) 01/2021 - 06/2003
77	Breast Neoplasms (Breast Cancer) 01/2021 - 01/2006
42	Neoplasm Metastasis (Metastasis) 01/2021 - 08/2007
14	Carcinogenesis 10/2017 - 06/2003
13	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 04/2010
12	Hypoxia (Hypoxemia) 01/2020 - 04/2010
10	Inflammation (Inflammations) 10/2015 - 04/2010
5	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2020 - 04/2009
5	Melanoma (Melanoma, Malignant) 01/2018 - 10/2010
5	Starvation 11/2012 - 08/2011
5	Lymphatic Metastasis 04/2012 - 08/2010
5	Muscular Dystrophies (Muscular Dystrophy) 04/2010 - 01/2002
4	Ovarian Neoplasms (Ovarian Cancer) 09/2017 - 01/2012
4	Prostatic Neoplasms (Prostate Cancer) 08/2009 - 08/2007
3	Infections 03/2020 - 03/2015
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 11/2011
3	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 05/2013
3	Communicable Diseases (Infectious Diseases) 09/2017 - 08/2013
3	5 Hypomyelinating Leukodystrophy 01/2012 - 10/2006
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 04/2010 - 10/2003
3	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 02/2010 - 01/2002
3	Hyperplasia 11/2006 - 06/2003
2	Disease Progression 01/2021 - 08/2009
2	COVID-19 10/2020 - 03/2020
2	Carcinoma (Carcinomatosis) 01/2017 - 04/2014
2	Tics (Tic) 06/2015 - 03/2015
2	Hypertrophy 05/2013 - 06/2012

Drug/Important Bio-Agent (IBA)

44	Caveolin 1IBA 01/2021 - 06/2003
32	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2003
31	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2009
30	Lactic Acid (Lactate)FDA LinkGeneric 01/2017 - 06/2010
21	AntioxidantsIBA 01/2021 - 09/2010
20	KetonesIBA 09/2013 - 09/2010
16	Pharmaceutical PreparationsIBA 01/2021 - 06/2009
16	Tamoxifen FDA LinkGeneric 01/2020 - 08/2008
14	Adenosine Triphosphate (ATP)IBA 01/2021 - 12/2009
12	EnzymesIBA 12/2017 - 02/2011
11	Doxycycline (Periostat)FDA LinkGeneric 03/2020 - 01/2015
10	Glutamine (L-Glutamine)FDA Link 04/2014 - 09/2010
10	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2012 - 08/2011
8	Estrogens (Estrogen)FDA Link 01/2020 - 11/2006
8	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 04/2011
8	Ketone BodiesIBA 10/2017 - 04/2012
8	CarcinogensIBA 10/2017 - 06/2003
7	Anti-Bacterial Agents (Antibiotics)IBA 03/2020 - 08/2013
6	Messenger RNA (mRNA)IBA 01/2020 - 10/2010
6	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 01/2012
5	Estrogen ReceptorsIBA 11/2019 - 11/2006
4	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2021 - 09/2015
4	CaveolinsIBA 01/2021 - 06/2009
4	Azithromycin (Zithromax)FDA LinkGeneric 03/2020 - 03/2015
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 08/2011
4	P-2 (P 2)IBA 01/2020 - 09/2017
4	Biological ProductsIBA 01/2019 - 02/2010
4	Proliferating Cell Nuclear Antigen (PCNA)IBA 09/2017 - 01/2014
4	Transcription Factors (Transcription Factor)IBA 09/2015 - 06/2010
4	Cyclin D1IBA 01/2014 - 06/2003
4	AntibodiesIBA 12/2012 - 06/2009
4	Chloroquine (Aralen)FDA LinkGeneric 12/2012 - 06/2010
4	PoisonsIBA 11/2012 - 04/2011
4	Caveolin 3IBA 02/2010 - 01/2002
3	bedaquiline (R207910)IBA 01/2021 - 01/2016
3	Mitochondrial Proton-Translocating ATPases (Mitochondrial ATP Synthase)IBA 01/2021 - 01/2016
3	Phenobarbital (Luminal)FDA Link 11/2019 - 01/2006
3	SolutionsIBA 09/2017 - 09/2010
3	DNA (Deoxyribonucleic Acid)IBA 06/2015 - 11/2012
3	Therapeutic UsesIBA 03/2015 - 12/2011
3	Estrogen Receptor alphaIBA 05/2014 - 06/2006
3	Amino Acids FDA Link 04/2014 - 09/2010
3	LigandsIBA 02/2013 - 08/2012
3	CytokinesIBA 05/2012 - 06/2011
3	CatalaseIBA 08/2011 - 05/2011
3	DystrophinIBA 04/2010 - 10/2003
3	Membrane Proteins (Integral Membrane Proteins)IBA 02/2008 - 10/2006
2	Coloring Agents (Dyes)IBA 01/2021 - 10/2003
2	Interleukin-6 (Interleukin 6)IBA 03/2020 - 02/2013
2	CholesterolIBA 01/2020 - 01/2011
2	ERRalpha Estrogen-Related ReceptorIBA 01/2020 - 09/2015
2	Small Interfering RNA (siRNA)IBA 11/2019 - 06/2010
2	GTP-Binding Proteins (G-Protein)IBA 12/2017 - 12/2017
2	Paclitaxel (Taxol)FDA LinkGeneric 08/2017 - 10/2015
2	palbociclibIBA 02/2017 - 10/2012
2	Telomerase (Telomerase Reverse Transcriptase)IBA 02/2017 - 09/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2015 - 09/2010
2	XCT790IBA 09/2015 - 06/2015
2	InterferonsIBA 05/2015 - 11/2012
2	Methionine (L-Methionine)FDA Link 03/2015 - 03/2008
2	Antineoplastic Agents (Antineoplastics)IBA 05/2013 - 12/2012
2	Cysteine (L-Cysteine)FDA Link 01/2013 - 11/2012
2	LipidsIBA 12/2012 - 12/2011
2	Milk Proteins (Milk Protein)IBA 11/2012 - 02/2009
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 09/2012 - 12/2011
2	Sirolimus (Rapamycin)FDA Link 07/2012 - 11/2010
2	AmmoniaIBA 12/2011 - 07/2011

Therapy/Procedure

58	Therapeutics 01/2021 - 08/2008
9	Drug Therapy (Chemotherapy) 01/2021 - 07/2010
5	Precision Medicine 09/2017 - 04/2011
4	Lasers (Laser) 01/2019 - 06/2006
3	Radiotherapy 01/2013 - 07/2010
2	Chemoprevention 01/2013 - 07/2012